NOAA’s Colorado Basin River Forecast Center provides seasonal water supply forecasts to a wide range of stakeholders in the Colorado River and Eastern Great Basins. These forecasts have traditionally relied on past historical climate information and tools created before widely available remote sensing data. Further, past historical hydroclimatic information, and our reliance on it, may not represent future conditions as climate change impacts are realized. The CBRFC is investigating forecast methodologies to aid stakeholders in decision support using newly available remote sensing information and stochastically generated future weather ensembles. Here, the CBRFC’s role in managing water resources is explained, and the challenges ahead for operational forecasts under changing climate conditions are discussed.